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Friday, July 24, 2020 | History

4 edition of Androgen receptor associated-protein 70 (ARA70) expression in breast cancer found in the catalog.

Androgen receptor associated-protein 70 (ARA70) expression in breast cancer

Androgen receptor associated-protein 70 (ARA70) expression in breast cancer

possible relationship with HER2/NEU overexpression.

  • 203 Want to read
  • 33 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2000.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL20801555M
ISBN 10061254205X
OCLC/WorldCa50790271

  Abstract. Androgen receptor (AR) belongs to the steroid hormone receptor family of the nuclear receptor superfamily and acts as a hormone-controlled transcription factor that conveys the .   MEMBRANE ANDROGEN RECEPTORS. The existence of a novel membrane-bound androgen receptor has been postulated by a number of authors based on the detection of specific androgen Cited by:

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen. Kay Marshall, in xPharm: The Comprehensive Pharmacology Reference, Targets-Pharmacodynamics. Androgen receptor antagonists competitively inhibit androgen binding to the androgen receptor. This nuclear receptor has three main domains; the ligand-binding domain, the DNA binding domain, and the amino terminal Ishioka et al ().Binding of agonist to the receptor .

NCOA4 (Nuclear Receptor Coactivator 4) is a Protein Coding gene. Diseases associated with NCOA4 include Differentiated Thyroid Carcinoma and Thyroid its related pathways are Pathways in cancer and Coregulation of Androgen receptor Ontology (GO) annotations related to this gene include transcription coactivator activity and androgen receptor . Uses of Androgen Receptor Test The blood sample is taken to the lab for analysis. The normal result for dehydroepiandrosterone sulphate is – ng/dl and for hydroxyprogesterone is ng/ml.


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Androgen receptor associated-protein 70 (ARA70) expression in breast cancer Download PDF EPUB FB2

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.

Key topics covered include: The discovery and cloning of the androgen receptor; -Androgen receptor Format: Hardcover. and androgen receptor expression has been reported in 70–95% of ovarian adenocarcinomas, implying a role in ovarian cancer cell biology.

Androgen receptor-associated protein 70 (ARA70) is a reported androgen receptor coactivator that enhances the trans-activational potential of the androgen receptor.

Androgen receptor (AR)-associated protein 70 (ARA70) was one gene found to be up-regulated by T3. The ARA70 is a ligand-dependent coactivator for the AR and was significantly increased by 4- to Cited by: Download Citation | On Jan 1,Alexandra Kollara and others published Androgen receptor associated-protein 70 (ARA70) expression in breast cancer, possible relationship with her2/neu.

Androgen receptor-associated protein 70 (ARA70) is a reported androgen receptor coactivator that enhances the transactivational potential of the androgen receptor up to fold. Because ARA70 expression could amplify androgen action Cited by: Androgen receptor (AR)-associated protein 70 (ARA70) was one gene found to be up-regulated by T3.

The ARA70 is a ligand-dependent coactivator for the Androgen receptor associated-protein 70 book and was significantly increased by 4- to. The cytoplasmic localization of Nuclear Receptor Coactivator 4 (NcoA4), also referred to as androgen receptor associated protein 70 (ARA70), indicates it may possess activities in addition to its.

Co-transfection studies indicate that HER2 (erbB-2) overexpression results in the phosphorylation and enhanced transcriptional activity of the androgen receptor (AR).

This Cited by:   Androgen receptor (AR)-associated protein 70 (ARA70) was one gene found to be up-regulated by T 3. The ARA70 is a ligand-dependent coactivator for the AR and was significantly Cited by: The androgen receptor gene StuI restriction site was found in all but one (%) of the 54 young bald men (p =) and in % of older balding men (p =) but in only % of nonbald men.

Cited by: Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone. It is one of the most abundant circulating steroids in humans. DHEA is produced in the adrenal glands, the gonads, and the brain.

It functions as a metabolic intermediate in the biosynthesis of the androgen CAS Number: Androgen Receptor Protein Conformation and Function. Similar to the other steroid receptors, unbound AR is mainly located in the cytoplasm and associated with a complex of heat shock proteins Cited by: While comparatively less toxic than chemotherapy, ADT has a number of important side effectsThese side effects are a consequence of the induced severe sex steroid deficiency, and, consistent with the widespread expression of sex steroid receptors Cited by: The androgen receptor (AR) is a nuclear receptor that functions as a transcription factor and regulates the development and growth of the prostate.

The AR, when bound by a ligand, complexes with DNA at androgen response elements in the promoter region of target genes. The transcriptional regulatory effects of the AR include pathways involved in cell growth and proliferation, cell cycle progression, protein Cited by: 1.

The first AR co-activator identified was Androgen Receptor Associated protein 70 (ARA70) in prostate cancer. ARA 70 works by increasing AR expression, protein stability and nuclear translocation. ARA 70 Cited by: 2. The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a ligand-dependent transcription facto r (TF) belonging to.

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen.

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones Aliases: AR, AIS, AR8, DHTR, HUMARA, HYSP1.

G.V. Sherbet, in Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy, Publisher Summary. Androgen receptor is a member of the steroid and nuclear hormone receptor family, which includes glucocorticoid and mineralocorticoid receptors, ER, PR, and the vitamin D3 receptor.

The activation of androgen receptor. Androgen receptor (AR) is a member of the superfamily of ligand responsive transcription regulators It functions in the nucleus where it is believed to act as a transcriptional.

NCOA4 Antibodies Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In .Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.

References Further reading. This article on a gene on human chromosome 1 is a stub. You can help Wikipedia Aliases: THRAP3, TRAP, thyroid hormone .Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding .